He was born on 15 February 1935 at Kofar Kaura in Lafia town to the family of Muhammad Al-Mustapha Marafa and Hajiya Halimatu respectively.
During his early age, he was enrolled into Quaranic school in Kofar Kaura Lafia and after acquiring some elementary aspects of Islamic knowledge and some chapters of the glorious Quran, he enrolled into Lafia Elementary School in 1943.
After obtaining his first school leaving certificate from Lafia elementary school in 1951, the teenage Isa Mustapha Agwai was admitted into Benue Provincial Middle School Katsina-Ala.
Having successfully completed his secondary school in Katsina-Ala in 1958, from the Katsina Middle School the young Isa Mustapha Agwai later registered at the Institute of Administration, Ahmadu Bello University Zaria in 1958 and obtained his Diploma certificate in Accountancy 1959.
He joined the service of Lafia Native Authority where he served as assistant treasurer, revenue officer and later pay-master in charge of the entire market of Lafia Native Authority.
Isa Mustapha Agwai apart from holding several government positions, he held the traditional title of Dan Galadiman and District head of Obi. The title conferred on him automatically brought him to a position of a full-time member Lafia Native Authority Council.
The Emir was one of the longest-serving traditional rulers in Africa, spanning over 45 years on the throne.
He was a peace lover, father to all and custodian of the African culture.
Dr.Isa Mustapha, died Thursday 10th January, 2019 after a protracted illness in a foreign hospital at the age of 84.